tag:blogger.com,1999:blog-3162625598067227745.post7992063247119799266..comments2023-05-19T02:09:36.856-07:00Comments on Mendelian Disorder: "Why I Don’t Want to Know My Genome Sequence"Anonymoushttp://www.blogger.com/profile/15925017686062610434noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-3162625598067227745.post-39026681239867114492012-12-11T00:43:36.837-08:002012-12-11T00:43:36.837-08:00MJ,
I am really curious what you learned about yo...MJ, <br />I am really curious what you learned about your migraines from your exome sequencing. Would you mind providing more details?<br />Thanks,<br />CeCeYour Genetic Genealogisthttps://www.blogger.com/profile/14696248341534125135noreply@blogger.comtag:blogger.com,1999:blog-3162625598067227745.post-9061707523119441392012-11-03T13:43:18.324-07:002012-11-03T13:43:18.324-07:00Thanks for your post.
I'm sorry if I came acr...Thanks for your post.<br /><br />I'm sorry if I came across as snide. I did not intend to deride those who choose to live in ignorance of their own genetics. As I said, many people make that choice and I think it's totally fair for them to feel that way. I know numerous geneticists who feel the same way. But those people do not simultaneously justify their feelings by denigrating the field's current ability to interpret the data, which is a new but rapidly advancing science, and that's really what bugged me about this article.<br /><br />There is a stark difference between DTC genomics in which you may find out things you don't want to know and clinical sequencing, in which results would be returned to you on a "need-to-know" basis. I think this is why we haven't seen 23andMe, for example, start to offer DTC exomes generally yet. They must recognize the risk of returning both incidental findings and clinically relevant findings that people may not want to know.<br /><br />All of that said, you may not want to know whether you have mutations predisposing you to Alzheimer's, but wouldn't you want your doctor to know that you have mutations predisposing you to breast cancer or prostate cancer? <br /><br />That's a problem with the post in question, in my opinion. It blends DTC and clinical sequencing together and treats them similarly.<br /><br />My response was also in part a response to the statements in that article that we don't really learn anything positive from getting ourselves sequenced that we wouldn't be able to learn from alternative assays. I completely disagree with those statements. Anonymoushttps://www.blogger.com/profile/15925017686062610434noreply@blogger.comtag:blogger.com,1999:blog-3162625598067227745.post-2442661187270897952012-11-03T12:49:23.328-07:002012-11-03T12:49:23.328-07:00I don't want my genome sequenced. I watch my ...I don't want my genome sequenced. I watch my grandfather through alzheimer's. My father was on the path when he died from other causes. I do not want to know if I have inherited that genetic risk. I want to live my life hoping I can look forward to my old age. If I had current health issues or if there was accessible early treatment then finding out for sure about the alzheimer's might be a price worth paying, but I don't and there isn't.<br /><br />I am glad your exome sequence was useful to you, but why the snide tone to those of us who make an active choice to live in ignorance?Anonymousnoreply@blogger.com